Oh, that's weird. So the year 3100? Around 700 years after Picard? I think Enterprise to Picard is like 250 years so that's quite a bit of timeline fuckery.
That video isn't much of a 'gotcha' then. The tranny worms could have become ubiquitous after all the known stuff.
Star Trek is one of the few places where a "pansexual vs bisexual" differentiation might actually make sense. Pretty unwoke of them to just go with bi.
But trans stuff has already existed in Star Trek a few times. There was that one Trill on TNG that was fucking Crusher as a man then that host body died and was replaced with a woman but Crusher wouldn't let her eat her asshole because the doctor was a homophobic Trump voter. In DS9 Dax was always talking about how great it was to have a cock with her old bodies until Worf started hollowing out her uterus. They also turned Quark into a woman for an episode and he closed some financial deal by showing the competition his sweet Ferengi tits and pussy. And I already brought up the member of that androgynous race that Riker fucked into becoming a woman.